GE, the GE Monogram, KTA, Amersham, Anotop, Benchkote, Capto, Cell Boost, Cy. The efficient virus removal provided by the chromatography medium also allows two-step purification of MAbs with Capto adhere ImpRes as the final polishing step (Fig 1). As part of the GE Healthcare BioProcess™ media platform, Capto ImpRes ion exchangers are manufactured under validated production methods, backed up with Regulatory Support Files, and have Secure Supply routines in place. research, visit GE Knowledge centre here. Capto Q ImpRes is a strong anion exchanger for high-throughput intermediate purification and polishing of a wide range of biomolecules. Capto adhere ImpRes is an excellent choice for purification of MAb with high aggregate content. “Capto ImpRes media have been designed to meet the throughput and high resolution needs of intermediate purification and polishing.”Ĭapto ImpRes media are available in several convenient formats, including Predictor™ 96-well filter plates and prepacked HiTrap™ and HiScreen™ columns to support all stages of biopharmaceutical development and manufacture. “The extension of the Capto platform with Capto ImpRes ion exchangers demonstrates our commitment to supporting biopharmaceutical manufacturers with the most modern tools to improve their processes in terms of throughput, productivity, and economy,” said Dr Nigel Darby, Vice President, Biotechnologies, GE Healthcare. The first Capto ImpRes products to be launched are Capto SP ImpRes and Capto Q ImpRes, strong cation and strong anion exchangers, respectively, that enable high throughput, high resolution polishing, and flexibility in process design.Ĭapto ImpRes media are based on a rigid high-flow agarose matrix that allows the use of high flow rates and higher bed heights, providing biopharmaceutical manufacturers with the possibility to reduce cycle times and maintain or reduce column equipment footprint, thus contributing to driving improvements in process economics. Elution was conducted with 20 mM Tris, pH 8.0 + 2 mM MgCl using a linear gradient of 2 480570 mM NaCl. GE Healthcare has extended its Capto™ platform to include Capto ImpRes ion exchange chromatography media for late-stage purification of a wide range of biomolecules. For capture, Capto Q ImpRes resin (HiScale 26 column, 88 mL 3 L scale or HiScale 50 column, 294 mL 10 L scale) was used. LC-MS innovation: Improve analytical accuracy This chromatography resin is part of an expanded high-resolution platform based on the high-flow agarose Capto product line. Which microbioreactor modules are best for you Capto SP ImpRes is a strong cation exchanger for the high-throughput intermediate purification and polishing steps of a wide range of biomolecules. Which solid support is right for your oligo synthesis? 10 cm bed height of HiScreen columns is designed to allow method optimization and parameter screening. Other GE ion exchange chromatography products GE Healthcares Life. Capto Q ImpRes is a strong anion exchange BioProcess medium, designed to meet the demands of modern large-scale manufacturers for fast, efficient, and cost-effective intermediate and polishing Protein purification.
Lab Automation, AI & Digital Transformation HiScreen Capto SP ImpRes column is packed with strong cation exchange modern resin.Food Contamination: Quality, Safety & Authenticity.2023 AACC Annual Scientific Meeting & Clinical Lab Expo.
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